Mammary Carcinoma in Female Rats Fed 2-Acetylaminofluorene.
نویسندگان
چکیده
Science, a weekly journal, In published each Friday by the American Association for the Advancement of Science at The Business Press, Incorporated, N. Queen St. and McGovern Ave., Lancaster, Pa. Founded in 1880, it has been since 1900 the official publication of the AAAS. Editorial and Advertising Offices, 1515 Massachusetts Avenue, N.W.. Washington k D. C. Telephone, EXecutive 60 or 01. Cable address, SCIMAG, Washington, D. C. Entered as secondclass matter at the Post Office at Lancaster, Pa., January 13,
منابع مشابه
Effects of 2-acetylaminofluorene on liver cell proliferation after partial hepatectomy of female rats.
The effect of the hepatocarcinogen 2-acetylaminofluorene (AAF) on liver regeneration in female Sprague-Dawley rats was studied. While livers of normal female rats were highly resistant to this carcinogen, partial hepatectomy of female animals maintained on diet containing 0.04% AAF disclosed a marked hepatotoxicity which resulted in abnormal, nodular regeneration. The incorporation of thymidine...
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INTRODUCTION Investigations in this laboratory on the carcino genic action of 2-acetylaminofluorene have re vealed that the type of diet fed with the carcinogen can influence the incidence and types of tumors in duced in rats. Female rats of the Alabama Experi ment Station (AES) strain uniformly developed mammary tumors in about 4 months when they were fed this carcinogen on a semi-purified die...
متن کاملProduction of tumors in rats by 2-aminofluorene and 2-acetylaminofluorene; failure of liver extract and of dietary protein level to influence liver tumor production.
The carcinogenic property of 2-acetylaminofluorene was first described by Wilson and his associates (9) in 1941. Of 39 rats that received the compound in the food at a level of 0.031 to 0.125 per cent for 95 or more days, 19 developed malignant tumors, and 8 animals had multiple tmnors. These included 10 bladder carcinomas; 8 epidermoid carcinomas of the side of the face; 3 mammary carcinomas; ...
متن کاملReduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.
The effects of dietary phénobarbital on hepatocarcinogenesis in rats fed 2-acetylaminofluorene (AAF) were studied. The simultaneous feeding of AAF and phénobarbital reduced the hepatocarcinogenic effects of AAF. In contrast, the sequential feeding of AAF and phénobarbital resulted in a significant increase in the incidence of hepatomas. No ill effects were observed in rats fed phénobarbital...
متن کاملHematologic status in DMBA-induced mammary gland carcinoma in sprague dawley rats
in this study,14 female sprague-dawley rats 55 days old were randomly divided into two control and experimental groups.2ml of 7,12-dimethylbenz{a} anthracene (DMBA) solution(20 mg of DMBA dissolved in 2 ml of corn oil) and 2 ml corn oil was eaten to each animal of test and control group respectively.tumor development was examined by milk line palpation once every week.during 3-5 months followin...
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ورودعنوان ژورنال:
- Science
دوره 108 2804 شماره
صفحات -
تاریخ انتشار 1948